Q1: What is the basic information?
A1: CAS No. 108050-54-0, Molecular Formula: C₄₆H₈₀N₂O₁₃. Appearance: White to pale yellow crystalline powder, slightly bitter taste. Insoluble in water, soluble in methanol, chloroform, DMF, and dilute acids (forming salts). Phosphate form is white to off-white powder, readily soluble in water.
Caution: Dust is irritating to eyes and skin; wear protective gear during handling.
Q2: What is its pharmacological action?
A2: Semi-synthetic macrolide antibiotic (tylosin derivative). Binds to 50S ribosomal subunit 23S rRNA → inhibits peptide chain elongation → blocks protein synthesis (primarily bacteriostatic; bactericidal against APP at high concentrations). Highly sensitive to porcine APP, HPS, Pasteurella multocida, and Mycoplasma (swine/poultry). Effective against some Streptococcus and Staph. aureus. Not sensitive to Gram-negative bacilli (E. coli, Salmonella).
Q3: What are its indications?
A3: Swine/bovine respiratory disease syndrome (APP, HPS, Pm, Mhp), avian CRD/airsacculitis (combined with doxycycline), bovine foot rot (local + systemic). Chicken/duck CRD (Mycoplasma) and MS infection—reduces mortality from airsacculitis and joint swelling. Combined with doxycycline for mixed Mycoplasma/E. coli infections. Contraindicated in laying hens.
Q4: What are the storage requirements?
A4: Sealed container, cool and dry warehouse.
