Q1: What is the basic information?
A1: CAS No. 70288-86-7, Molecular Formula: C₄₈H₇₄O₁₄. Appearance: White or off-white crystalline powder or flakes, odorless. Almost insoluble in water, soluble in methanol, ethanol, acetone, toluene, and chloroform.
Q2: What is its pharmacological action?
A2: Macrolide antiparasitic drug (avermectin derivative). Binds to GABA receptors and glutamate-gated Cl⁻ channels in parasites → Cl⁻ influx → hyperpolarization → neuromuscular paralysis → death. Highly effective against nematodes and arthropods (mites, lice, ticks, scabies mites, itch mites). Ineffective against trematodes and tapeworms. Lacks GABA-mediated pathway in mammalian BBB → wide therapeutic window.
Q3: What are its indications?
A3: Internal/external parasites in cattle, sheep, pigs—gastrointestinal nematodes, lungworms, scabies mites, itch mites, lice, ticks, kidney worms. Prevention of heartworm in dogs/cats (micro-dose), ear mites, scabies mites. Eliminates nematodes and external parasites in chickens/turkeys/pigeons/quails (spray/injection). Generally contraindicated in laying hens during egg production.
Q4: What are the storage requirements?
A4: Sealed container, cool and dry place. Keep away from oxidizers. Store at 2–8°C.
