描述
CAS No. 70288-86-7
Molecular Formula: C48H74O14
Appearance: White or off-white crystalline powder or flakes, odorless; almost insoluble in water, soluble in methanol, ethanol, acetone, toluene, and chloroform
Pharmacological Action: Macrolide antiparasitic drug (avermectin derivative). It binds to GABA receptors and glutamate-gated Cl⁻ channels in the parasite’s nerve/muscle cells → Cl⁻ influx → hyperpolarization → neuromuscular paralysis → parasite rigidity and death. Highly effective against nematodes (tapeworms/trematodes) and spider insects (mites, lice, ticks, scabies mites, itch mites); ineffective against trematodes and tapeworms; lacks GABA-mediated pathway in the mammalian BBB → wide therapeutic window.
Indications: Internal and external parasites in cattle, sheep, and pigs—gastrointestinal nematodes (Haemaphysalis/Oster/Trichophyton/Esophagocytoid/Strongyloides, etc.), lungworms (Ducella), scabies mites, itch mites, lice, ticks, and pig kidney worms; prevention of heartworm in dogs and cats (micro-dose formulation), ear mites, and scabies mites.
Eliminating nematodes (roundworms, capillary nematodes) and external parasites (feather lice, rare fowl mites/scabies mites) in chickens/turkeys/pigeons/quails; often formulated as a spray/injection for deworming breeder flocks; generally contraindicated in laying hens during egg production (fat-soluble residues).
Storage Conditions: Store in a sealed container in a cool, dry place. Keep away from oxidizers. Store at 2-8 ºC.
