描述
CAS No. 108050-54-0
Molecular Formula: C46H80N2O13
Appearance: White to pale yellow crystalline powder, slightly bitter taste; insoluble in water, soluble in methanol, chloroform, DMF, and dilute acids (forming salts); phosphate is a white to off-white powder, readily soluble in water.
Caution: Tilmicosin raw material dust is irritating to eyes and skin; wear protective gear during handling.
Pharmacological Action: Semi-synthetic macrolide antibiotic for livestock and poultry (tylosin derivative). Binds to bacterial 50S ribosomal subunit 23S rRNA → inhibits peptide chain elongation → inhibits protein synthesis (primarily antibacterial; high concentrations are bactericidal against APP). Highly sensitive to porcine APP (Actinobacillus pleuropneumoniae), HPS (Haemophilus parasuis), Pasteurella multocida, and Mycoplasma (swine/poultry); effective against some Streptococci and Staphylococcus aureus; not sensitive to Gram-negative bacilli (Escherichia coli, Salmonella).
Indications: Swine/bovine respiratory disease syndrome (APP, HPS, Pm, Mhp), avian chronic respiratory disease/air sacculitis (in combination with doxycycline), bovine foot rot (local + systemic).
Chicken/duck chronic respiratory disease (CRD/Mycoplasma), Mycoplasma synoviae (MS) infection—reduces mortality from air sacculitis and joint swelling; used in combination with doxycycline to control mixed infections of Mycoplasma and Escherichia coli; contraindicated in laying hens.
Storage Conditions: Store in a sealed container in a cool, dry warehouse.
