Florfenicol

Florfenicol is an animal-specific broad-spectrum antibacterial antibiotic (florfenicol) belonging to the amide class. It inhibits protein synthesis by binding to the 50S ribosomes of bacteria. It is mainly used to prevent and treat respiratory infections (such as pleuropneumonia and Haemophilus parasuis infection), Escherichia coli infection, and salmonellosis in pigs, cattle, and poultry.

Q1: What is the basic information?

A1:
CAS No. 73231-34-2
Molecular Formula: C₁₂H₁₄Cl₂FNO₄S
Appearance: White or off-white crystalline powder, odorless, bitter taste. Very slightly soluble in water (≈1.3 mg/mL), slightly soluble in glacial acetic acid, soluble in methanol, ethanol, DMF, and DMSO. Contains no chloramphenicol nitro group, poses no risk of aplastic anemia.

Q2: What is its pharmacological action?

A2: Amide alcohol broad-spectrum antibiotic (animal-specific). Binds to 50S ribosomal subunit → inhibits peptidyl transferase → blocks peptide chain elongation → inhibits protein synthesis. Effective against G⁺/G⁻ bacteria and mycoplasma, especially sensitive to Actinobacillus pleuropneumoniae, Haemophilus parasuis, Pasteurella multocida, Streptococcus, E. coli, Salmonella, and Haemophilus. Still effective against chloramphenicol-resistant strains.

Q3: What are its indications?

A3: Swine/bovine respiratory syndrome (APP, HPS, Pm, Mhp), avian E. coli/Salmonella/chronic respiratory disease, bovine foot rot, aquatic Aeromonas hydrophila infection.

Q4: What are the storage requirements?

A4: Sealed, protected from light, cool and dry place (<25°C).