Doxycycline Hyclate

Doxycycline Hyclate is a broad-spectrum antibacterial semi-synthetic tetracycline (doxycycline hydrochloride), which inhibits protein synthesis by binding to bacterial 30S ribosomes. It is mainly used to prevent and treat Gram-negative/Gram-negative bacterial and mycoplasmal infections in pigs and poultry, such as mycoplasma pneumonia, porcine swine dysentery, ileitis, and pasteurellosis.

Q1: What is the basic information?

A1:
CAS No. 24390-14-5
Molecular Formula: C₂₂H₂₄N₂O₈·HCl·½H₂O·½C₂H₆O
Appearance: Pale yellow to yellowish-brown crystalline powder, bitter taste, hygroscopic. Readily soluble in water and methanol, slightly soluble in ethanol, practically insoluble in chloroform and ether. Gradually changes color upon light exposure.

Q2: What is its pharmacological action?

A2: Semi-synthetic tetracycline antibiotic, 2–10 times more active than oxytetracycline, effective against many tetracycline-resistant bacteria. Binds to 30S ribosome A site → blocks aminoacyl-tRNA → inhibits protein synthesis. Effective against G⁺/G⁻ bacteria, mycoplasma, rickettsia, chlamydia, and some protozoa (eperythrozoonosis, toxoplasmosis).

Q3: What are its indications?

A3: Prevention and treatment of swine/avian mycoplasmal pneumonia, eperythrozoonosis, toxoplasmosis (combined with sulfonamides), swine dysentery, ileitis, pasteurellosis, avian CRD/airsacculitis, bovine transport fever, and aquatic vibriosis.

Q4: What are the storage requirements?

A4: Sealed, protected from light, cool and dry (<25°C), keep away from moisture.