Lincomycin Hydrochloride

Lincomycin Hydrochloride is a lincomycin-based antibacterial antibiotic (lincomycin hydrochloride). It inhibits protein synthesis by binding to bacterial 50S ribosomes, resulting in high concentrations in bone tissue. It is primarily used to prevent and treat infections caused by Gram-negative bacteria and anaerobic bacteria, such as swine dysentery caused by Treponema pallidum, necrotizing enteritis, mycoplasmal pneumonia, and Mycoplasma synoviae infection in chickens.

Q1: What is the basic information?

A1:
CAS No. 859-18-7
Molecular Formula: C₁₈H₃₅ClN₂O₆S
Appearance: White or off-white crystalline powder, bitter taste. Readily soluble in water (>500 mg/mL), soluble in methanol and ethanol, practically insoluble in chloroform and ether. Aqueous solution pH ≈ 3.0–5.5, stable.

Q2: What is its pharmacological action?

A2: Lincosamide antibacterial antibiotic. Binds to bacterial 50S ribosomal subunit 23S rRNA → inhibits peptide chain translocation → blocks protein synthesis. Highly effective against Gram-positive bacteria (Streptococcus, Staphylococcus aureus, Corynebacterium pyogenes) and anaerobic bacteria (Clostridium perfringens); partially effective against mycoplasma. Generally insensitive to Gram-negative aerobic bacteria. Achieves high concentration in bone tissue.

Q3: What are its indications?

A3: Swine dysentery caused by Treponema pallidum, necrotic enteritis in swine/poultry (Clostridium perfringens), adjunctive treatment for swine mycoplasmal pneumonia, avian mycoplasma synoviae infection (in combination with aminoglycosides), soft tissue and bone infections in cattle/dogs.

Q4: What are the storage requirements?

A4: Store in a sealed container at 2–8°C.